***Any changes to supplementation or diet should be discussed with your doctor***
1) WHAT ARE PARENTS SEEING IN THEIR CHILDREN USING THE RESPEN-A™ DISC?
Many parents are reporting in the first month of using the Respen-A™ Disc increased
concentration, better eye contact, more socialization, less irritability, decreased anxiety, and
some children who were unable to speak are now trying to verbally communicate once again.
2) WHAT ARE THE SIDE EFFECTS OF THE RESPEN-A™ DISC?
Some parents have reported increased aggressiveness and irritability, which may be an
indication that the child is not getting enough calcium or inadequate absorption of the calcium.
Some parents have reported a lessening in the aggressive behavior or irritability by changing the
form of calcium from calcium citrate to calcium carbonate or vice versa. Oral calcium
supplementation has been a challenge for parents in the past, but we have resolved this by
formulating a transdermal calcium/magnesium skin cream which is included with each month
supply of Respen-A™.
Generally the duration of wearing time of the Respen-A™ Disc is from morning until
bedtime, but this can vary depending on the individual child. If you see a regression in behavior
after applying the disc or wearing it for a few hours, remove the disc, as it may be that your child
doesn’t need to wear it any longer that day.
3) DOES THE DOSE NEED TO BE ADJUSTED DEPENDING ON MY CHILD’S WEIGHT?
We have not found that body weight has any bearing on the dosage.
4) WHERE IS THE BEST PLACE ON THE CHILD TO ADHERE THE RESPEN-A™ DISC?
We suggest the Respen-A™ Disc be placed on the child’s torso. Many parents have
placed the disc between the shoulder blades, so that the child cannot reach it to remove it.
5) WHY IS IT SO IMPORTANT THAT MY CHILD SUPPLEMENT CALCIUM DAILY WITH THE RESPEN-A™ DISC?
The active ingredient in the Respen-A™ Disc is reserpine. Reserpine has been shown to
significantly decrease the storage capacity of calcium in the cells and it stimulates the excretion
of calcium in urine and movement of calcium into the bones. These actions can lower the blood
and intracellular calcium levels. Low calcium levels can cause symptoms of irritability,
aggressiveness, numbness and tingling in the hands, feet and face, muscle spasms and stiffness.
Calcium is necessary to get the best effect from the Respen-A™ Disc. Reserpine
stimulates the activity of MAO-A, a mitochondrial enzyme. The activity of MAO-A is enhanced
Thus, to get the best effect of the Respen-A™ Disc and avoid symptoms of low calcium,
it is necessary to administer ½ teaspoon of the calcium/magnesium skin cream that is included
with a month supply of Respen-A™ in the morning prior to applying the Respen-A™ disc.
6) DOES IT MATTER IF I PUT THE RESPEN-A™ DISC ON BEFORE MY CHILD APPLIES THE CALCIUM/MAGNESIUM SKIN CREAM?
Most parents have reported the best results giving the calcium supplement before putting on the Respen-A™ Disc. If your child is displaying symptoms of aggression, irritability, or a worsening of his core symptoms shortly after applying the Respen-A™ Disc, then he or she may need to have the calcium/magnesium skin cream applies at least 30 minutes prior to applying the
7) IF THE DOSE OF THE RESPEN-A™ IS REDUCED TO A HALF DISC SHOULD THE CALCIUM BE DECREASED?
The calcium requirements are the same whether a full disc or a half disc is used.
8) WHY DO YOU SUGGEST THAT CHILDREN USING THE RESPEN-A™ DISC NOT BE ON THE ESSENTIAL FATTY ACIDS IN THE OIL FORM?
We found that the oils such as fish oil, flaxseed oil, primrose oil, cod liver oil, etc will
negate the effects of the Respen-A™ Disc. The oils are made up of double bonds, and once the
body breaks down these double bonds, it creates lipid peroxides. Lipid peroxidation will
decrease monoamine oxidase-A (MAO-A) and we are trying to increase MAO-A activity.
Therefore, we suggest that the child not use the oils and instead eat a serving of fish weekly.
If the child has been on these oils for several months or more, it may take up to three
weeks for the effects of these oils to be cleared.
Also Tumeric (also called Curcumin) supplements will negate the Respen-A™ Disc.
Tumeric inhibits MAO-A.
Also Papain and Licorice Root (Anise) that is often in some digestive enzyme
supplements will inhibit MAO-A so it should not be taken with the Respen-A™ Disc.
Also Quercetin, L-carnitine, L-carnosine, and Cat’s Claw can diminish the effects of
9) WHY DO YOU SUGGEST NOT TO TAKE DOSES OF 30 mg OR HIGHER OF
VITAMIN B6 IN THE FORM OF PYRIDOXINE HYDROCHLORIDE? BUT PYRIDOXAL 5-PHOSPHATE IS OKAY?
After gathering data from patients using the Respen-A™ Disc, we have found that some
patients taking vitamin B6 in the form of pyridoxine hydrochloride in doses of 50 mg or greater
have seen a loss of some of their improvements from the Respen-A™ Disc such as decreased
speech and attentiveness. Upon stopping the pyridoxine hydrochloride supplementation, the
improvements seen with the Respen-A™ Disc were regained. Pyridoxine hydrochloride is the
common form of vitamin B6 in most multivitamin supplements, but the dosage is usually less
than 50 mg and this has not been reported as causing a problem. The more active form of
vitamin B6, pyridoxal 5-phosphate (P-5-P) has not been shown to interfere with the Respen-A™
10) WHY DO YOU SUGGEST NOT TAKING SUPPLEMENTS OF L-GLUTAMINE or GABA?
Glutamine and alanine are the most abundant amino acids generally in the body.
Glutamine and alanine are associated with the MAO-B pathway. MAO-B is the counterbalance
to MAO-A, and can decrease the activity of MAO-A. Glutamine and GABA may possibly
increase MAO-B activity therefore decreasing MAO-A activity, which counteracts the Respen-
A™ trying to boost MAO-A.
11) DOES THE RESPEN-A™ DISC REQUIRE A SPECIFIC DIET?
Some children on the gluten free diet have seen a return of symptoms after seeing good
improvement on the Respen-A™ Disc and some children have seen no results or even a
worsening of their symptoms when starting the Respen-A™ Disc. One parent noticed that if her
child had a small amount of gluten, the symptoms resolved. A few more parents have reported
the same findings with incorporating some gluten back in their children’s diet. Researching the
scientific rationale for this, it was discovered that L-Tryptophan, 5-HTP, increase the production
of serotonin. This newly synthesized serotonin is put into storage vesicles in the cells. The
Respen-A™ Disc turns over the serotonin in the synapse (the junction between nerves). The
serotonin needs to be released from these storage vesicles into the synapse so that the Respen-
A™ Disc can stimulate the conversion of the serotonin into the active aldehyde. Research shows
that gluten will stimulate the release of serotonin from the storage vesicles.
A vegetarian diet is not recommended when using the Respen-A™ Disc. It is necessary
to eat a serving of meat every day when using the Respen-A™ Disc as meat is the primary
source of tryptophan in the diet which is needed to produce serotonin. If a person doesn’t get
enough tryptophan in their diet, they can become depressed when using Respen-A™. If the child
cannot handle meat in their diet, we suggest they take 5-HTP. 5-HTP is the supplement of
choice, however, 100-150 mg will need to be given 3-4 times a day as it doesn’t store in the
body. If this is not feasible for your child, you can supplement with L-Tryptophan 500 mg daily,
one time a day, as it does store in the body.
If your child is on a gluten free diet inositol supplementation may be necessary. In most
cases, 500 mg to 700 mg a day of inositol has been adequate in the release of serotonin to keep
up with the turnover stimulated by Respen-A™ Disc. Inositol is available in a powder or capsule
from various manufactures. It virtually is tasteless and dissolves well in water. Early reports
show that a once a day dosing has been adequate, but depending on the child, you may find that
dividing the dose up into three servings a day may be beneficial. The inositol has a long acting
effect in stimulating the release of serotonin and norepinephrine so if your child will not be
wearing the disc for several continuous hours one day (i.e. one day at the beach and in and out of
the water several times in which the disc gets removed and replaced several times throughout the
day) then it is recommended to not supplement with inositol that day but rather use small
amounts of gluten instead that day.
If you have not previously been on the Respen-A™, it is then recommended to start
the Inositol 500mg/day after about 5-7 days of being on the Respen-A™ OR starting the
Inositol prior to this 5-7 day period ONLY IF the child exhibits an increase in autism
symptoms. (The reason for this is that we need to decrease the serotonin with the Respen-A™
BEFORE giving Inositol, otherwise the child’s serotonin will actually become too high and
symptoms of autism will arise). The inositol should be given at least 15 minutes after
applying the Respen-A™ Disc, not before applying the Respen-A™ Disc and the Respen-
A™ Disc should be worn for 2-3 hours after taking inositol.
12) WHAT IF MY CHILD’S SYMPTOMS RETURN ON THE RESPEN-A™ DISC?
Some children on the gluten free diet have seen a return of symptoms after seeing good
improvement on the Respen-A™ Disc and some children have seen no results or even a
worsening of their symptoms when starting the Respen-A™ Disc. We thought that this may be
due to a depletion of their serotonin by the Respen-A™, so we recommended that they take 5-
HTP or L-Tryptophan to replenish the serotonin. Several of the parents reported that this made
no difference, but one parent noticed that if her child had a small amount of gluten, the
symptoms resolved. A few more parents have reported the same findings with incorporating
some gluten back in their children’s diet. Researching the scientific rationale for this, it was
discovered that L-Tryptophan, 5-HTP, increase the production of serotonin. This newly
synthesized serotonin is put into storage vesicles in the cells. The Respen-A™ Disc stimulates
the turnover of the serotonin in the synapse (the junction between nerves). The serotonin needs
to be released from these storage vesicles into the synapse so that the Respen-A™ Disc can
stimulate its conversion into the active aldehyde. Research shows that gluten will stimulate the
release of serotonin from the storage vesicles.
If you see some return of symptoms on the Respen-A™ and your child is already using
inositol then it may be that your child needs inositol more than once a day or it may be that your
child isn’t converting well the L-tryptophan in the meat into 5-HTP that is then converted into
serotonin. How to determine if it is a case of needing more inositol; if your child does well in
the morning after taking inositol but is exhibiting more symptoms in the afternoon, then try
giving your child a second dose of inositol in the afternoon. Be sure to keep the Respen-A™
disc on for 2-3 hours after giving the second dose of inositol. If this increase in the inositol
doesn’t resolve the symptoms then it may be that your child isn’t easily converting L-tryptophan
from the meat he/she is eating into 5-HTP; try supplementing 5-HTP 100 mg 3-4 times a day and
see if this improves the symptoms.
Ultimately we are trying to achieve a balance in the amount of serotonin produced from
the L-tryptophan/5-HTP that is then released from the cells storage into the nerve junctions by
the inositol. The serotonin that is released into the nerve junctions is then converted by MAO-A
into the active aldehyde and it is the Respen-A™ that is stimulating the MAO-A activity. Think
of it as an equation: A + B + C = D, where A equals the amount of L-tryptophan/5-HTP to make
the serotonin; B equals the amount of inositol to release the serotonin into the nerve junctions; C
equals the amount of Respen-A™ needed to activate the MAO-A to turn over the serotonin into
the active aldehyde which is D. It takes a little bit of trial and error to get the equation balanced
for each child.
13) WHAT IF MY CHILD’S IMPROVEMENTS ON RESPEN-A™ HAVE REACHED A PLATEAU?
If you feel that your child’s improvements have reached a plateau or that there seems to
be some hurdle they just can’t get over, it may be a co-existing condition called pyroluria.
Pyroluria is common in autism, ADD, ADHD and depression. Pyroluria is the result of a
buildup of the waste products called kryptopyroles from the production of hemoglobin. The
symptoms of pyroluria are very similar to many of the symptoms associated with autism. The
treatment for pyroluria is supplementation of zinc, vitamin B6 in the form of pyridoxal 5-
phosphate (P5P) and eating foods high in arachidonic acid which are eggs, butter, red meat and
liver. If your child won’t eat these foods, you can buy a supplement of arachidonic acid from
Molecular Nutrition called X Factor. It is available in 250 mg soft gel caps at
www.mnbody.com. A website to learn more about pyroluria is www.primalbodyprimalmind.
14) HOW LONG IS THE SHELF LIFE OF THE RESPEN-A™ DISC?
Each Respen-A™ Disc has a shelf life of 365 days in its original package. Therefore, we
can ship 12-month supply of the Respen-A™ Discs at a time to decrease the cost of shipping if
Once the Respen-A™ Disc has been activated on the skin, it is active for 20-24 hours.
This is why we suggest you put a disc on the child in the morning and then remove it when they
go to bed at night. The adhesive tape included with the Respen-A™ discs is waterproof so your
child can swim or shower while wearing the Respen-A™ disc.
15) HOW CAN I RECEIVE ADDITIONAL INFORMATION ON THE RESPEN-A™ DISC?
If you have any troubleshooting questions about Respen-A™, or any testimonials you
want to share of results using the Respen-A™ Disc, please call us at the same number 360-652-
2816 as we would love to speak with you.
16) Do I Need a Prescription for RESPEN-A™?
Yes, Respen-A has been prescribed by 130 doctors to more than 900 patients. Several of these doctors are taking new patients and are listed on our website.
17) Does RESPEN-A™ Have Bad Side Effects?
Many side effects have been associated with higher doses of reserpine due to the metabolites or end products of the reserpine molecules. Because Respen-A is a homeopathic dilution of reserpine, containing only the frequency of reserpine and not the metabolites, none of the side effects of reserpine have been reported using Respen-A. Side effects known for reserpine include: vomiting, nausea, diarrhea, dryness of mouth, anorexia, arrhythmias, edema, nasal congestion, dyspnea, depression, nervousness, nightmares, drowsiness, dull sensorium, muscular aches, pseudolactation, impotence, dysuria, decreased libido, weight gain, deafness, optic atrophy, glaucoma, uveitis, purpura, rash, and pruritus.
18) What is RESPEN-A™?
Respen-A is a 12C homeopathic dilution of reserpine. Reserpine has been shown to double the activity of the monoamine oxidase-A (MAO-A) enzyme. (ViJayalakshmi V., Lele J.V., & Daginawala H.F. 1978. Effect of reserpine on the monoamine oxidase (MAO) activity in rat liver and brain. Biochemical Pharmacology, 27(15), pp. 1985-1986.)
19) How Does RESPEN-A™ Work?
Studies show that patients with autism have lower or decreased MAO-A activity. This deficiency can result in symptoms associated with autism.
20) Is RESPEN-A™ a New Drug?
Reserpine has been used in autistic patients as far back as 1957. (Lehman E., Haber J., & Lesser S., July-Sept 1957, The use of reserpine in autistic children. The Journal of Nervous and Mental Disease, 125(3), pp. 351-356.)
21) What is a Homeopathic Drug?
Homeopathic drugs use minimal or smaller amounts of natural substances (i.e., chemicals that are present in the human body or exist in nature) to stimulate the body’s own healing reactions. If larger amounts of the same substances are administered, they can cause adverse events.
Every molecule has a unique structure and therefore every molecule has a unique vibration because of the way light and sound bounce off of the structure. Recent research has determined that these vibrations are actually photons that can be imprinted into a water molecule similar to a camera bouncing light off an object and imprinting the image onto a negative.
Molecules don’t like to exist singularly though, they congregate with like molecules, and therefore in order to get the pure vibration (the vibration off of the structure of just one molecule) you must perform serial dilutions with vigorous shaking. These homeopathic vibrations have been scientifically quantified to produce physiological effects. https://link.springer.com/article/10.1007/s00011-009-0044-4 , https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2125.1988.tb03327.x
22) What Scientific Studies Support the Use of RESPEN-A™?
The Respen-A 12C homeopathic topical disc has been shown in an open label clinical study conducted by Dr. Anju Usman to have a statistically significant effect (p < 0.001) in lessening the core symptoms associated with autism. The evaluation methods utilized were the ATEC and CARS, the former is an evaluation performed by the parent and the latter is an evaluation performed by a licensed healthcare provider. Respen-A had to have a very strong effect in order to show a statistically significant effect because of the (i) small size of the study, (ii) the patients in the clinical trial had moderate to severe autism, and (iii) the patients were older (mean age 13.5 years). The results of Dr. Usman’s study are consistent with the testimonials on the Video Testimonials and Written Testimonials pages on the website. You can see more testimonials on the Respen-A Facebook page. https://www.facebook.com/pg/Respenaforautism/posts/
We also have a Facebook page relating to Respen-A™. The blog discusses many topics,
not only regarding Respen-A™, but other Autism treatments and how they react with the
Respen-A™ Disc. You can visit both of these sites by visiting our website at www.respen-a.com and clicking on the links on the home page.